ANCA - ANTIGEN TARGETS
& AI DISEASES.HTML
LABORATORY
STANDARD IN THE DIAGNOSIS AND THERAPY MONITORING OF
AUTOIMMUNE DISEASES -
Tuesday, 12 September 2006
http://www.ifcc.org/index.php?option=com_content&task=view&id=346&Itemid=31
EJIFCC 2006, 17(3) Paper 9Antineutrophil cytoplasmic antibodies
(ANCA) staining patterns and associated target antigen in patients with
systemic vasculitides and nonvasculitic disorders
WG-Wegener's granulomatosis;
MPA-microscopic polyangiitis; CSS-Churg-Strauss syndrome; UC-ulcerative
colitis; CD-Crohn's disease; PSC-primary sclerosing cholangitis;
SLE-systemic lupus erythematosus; RA-rheumatoid arthritis;
AIH-autoimmune hepatitis; HLE-human leukocyte elastase;
BPI-bacteridical/permeability-increasing protein; HMG1/2-high mobility
group of non-histone chromosomal proteins 1 and 2
| IMMUNOFLUORESCENCE PATTERN |
ANCA TARGET ANTIGEN |
ASSOCIATED DISEASE |
| C-ANCA |
PR3
|
WG |
| P-ANCA |
MPO |
MPA, CSS |
| P-ANCA |
HLE |
UC, CD, PSC, SLE |
| P-ANCA |
α-enolase |
|
| P-ANCA |
catalase |
|
| P-ANCA |
azurodicin (AZ) |
|
| P-ANCA (atypical) |
lactoferrin (LF) |
UC, CD, PSC |
| P-ANCA (atypical) |
cathepsin G (CG) |
UC, CD, PSC, SLE, RA |
| P-ANCA (atypical) |
lysozyme (LZ) |
UC, CD, PSC |
| C-ANCA, P-ANCA (atypical) |
actin |
AIH |
| C-ANCA, P-ANCA (atypical) |
BPI |
UC, CD, PSC, AIH, SLE |
| P-ANCA (atypical) |
HMG1/2 |
UC, SLE, RA |
| P-ANCA (atypical) |
lamine B1 |
UC, CD, SLE |
| P-ANCA (atypical) |
histone H1 |
UC |
| P-ANCA (atypical) |
50 Kd |
UC, AIH |